Buy Zebeta Online

Zebeta (bisoprolol fumarate)

THERAPEUTIC CLASS

Selective beta1 blocker

DEA CLASS

RX

INDICATIONS

Management of HTN alone or in combination with other antihypertensive agents.

ADULT DOSAGE

Hypertension

Initial: 5mg qd
Titrate: May increase to 10mg and then, if necessary, to 20mg qd

DOSING CONSIDERATIONS

Renal Impairment
CrCl <40mL/min:
Initial: 2.5mg qd; use caution w/ dose titration

Hepatic Impairment
Initial: 2.5mg qd; use caution w/ dose titration

Other Important Considerations
Patients w/ Bronchospastic Disease:
Initial: 2.5mg qd

ADMINISTRATION

Oral route

HOW SUPPLIED

Tab: 5mg*, 10mg *scored

CONTRAINDICATIONS

Cardiogenic shock, overt cardiac failure, 2nd- or 3rd-degree atrioventricular (AV) block, marked sinus bradycardia.

WARNINGS/PRECAUTIONS

Avoid abrupt withdrawal; exacerbation of angina pectoris, MI, and ventricular arrhythmia in patients with coronary artery disease, and exacerbation of symptoms of hyperthyroidism or precipitation of thyroid storm reported. Reinstitute temporary therapy if withdrawal symptoms occur. May mask manifestations of hypoglycemia or clinical signs of hyperthyroidism (eg, tachycardia). Caution with compensated cardiac failure, diabetes mellitus, bronchospastic disease, and hepatic/renal impairment. May precipitate cardiac failure; d/c at the 1st signs/symptoms of heart failure (HF) or continue therapy while HF is treated with other drugs. Caution with peripheral vascular disease; may precipitate or aggravate symptoms of arterial insufficiency. Caution with history of severe anaphylactic reaction to a variety of allergens; reactivity may increase with repeated challenge.

ADVERSE REACTIONS

Headache, URI, peripheral edema, fatigue, ALT/AST elevation.

DRUG INTERACTIONS

Patients with a history of severe anaphylactic reaction to a variety of allergens taking β-blockers may be unresponsive to usual doses of epinephrine. D/C several days before withdrawal of clonidine. Excessive reduction of sympathetic activity with catecholamine-depleting drugs (eg, reserpine, guanethidine); monitor closely. Avoid with other β-blockers. Caution with myocardial depressants or inhibitors of AV conduction, such as calcium antagonists (eg, verapamil, diltiazem) or antiarrhythmics (eg, disopyramide). Increased risk of bradycardia with digitalis glycosides. Increased clearance with rifampin. Caution with insulin or oral hypoglycemic agents. Reversed effects with bronchodilator therapy. Additive BP lowering effects in mild to moderate HTN with HCTZ.

PREGNANCY AND LACTATION

Category C, caution in nursing.

MECHANISM OF ACTION

β1-selective adrenoreceptor blocking agent; not established. May decrease cardiac output, inhibit renin release by the kidneys, and diminution of tonic sympathetic outflow from the vasomotor centers in the brain.

PHARMACOKINETICS

Absorption: (10mg) Absolute bioavailability (80%); Cmax=(5mg) 16ng/mL, (20mg) 70ng/mL; (5-20mg) Tmax=2-4 hrs. Distribution: Plasma protein binding (30%). Elimination: Urine (50%, unchanged), feces (<2%); T1/2=9-12 hrs.

ASSESSMENT

Assess for conditions where treatment is contraindicated or cautioned, pregnancy/nursing status, and possible drug interactions.

MONITORING

Monitor for hypoglycemia, hyperthyroidism, hepatic/renal function, signs/symptoms of HF, withdrawal, and arterial insufficiency. Monitor HR, ECG, CBC with platelet and differential count.

PATIENT COUNSELING

Instruct not to interrupt or d/c therapy without consulting physician. Notify physician if difficulty in breathing, signs/symptoms of CHF or excessive bradycardia develop. Educate about signs/symptoms of drug's potential adverse effects. Advise to exercise caution while driving, operating machinery, or engaging in other tasks requiring alertness.

STORAGE

20-25°C (68-77°F). Protect from moisture.

TAGS

order bisoprolol online, where i buy zebeta usa, buy bisoprolol, zebeta, buy zebeta 10mg online no prescription, buy zebeta, buy cheap bisoprolol, buy zebeta without prescription, purchase bisoprolol, buy bisoprolol online, purchase bisoprolol online, generic bisoprolol, order bisoprolol