Buy Vantin Online

Cefpodoxime (cefpodoxime proxetil)

OTHER BRAND NAMES

Vantin (Discontinued)

THERAPEUTIC CLASS

Cephalosporin (3rd generation)

DEA CLASS

RX

INDICATIONS

Treatment of mild to moderate infections (acute otitis media, pharyngitis, tonsillitis, community-acquired pneumonia [CAP], acute bacterial exacerbation of chronic bronchitis [ABECB], acute uncomplicated urethral and cervical gonorrhea, acute uncomplicated anorectal infections in women, uncomplicated skin and skin structure infections [SSSIs], acute maxillary sinusitis, and uncomplicated urinary tract infections [UTIs] [cystitis]) caused by susceptible strains of microorganisms.

ADULT DOSAGE

Tonsillitis and/or Pharyngitis

100mg q12h for 5-10 days

Community-Acquired Pneumonia

200mg q12h for 14 days

Acute Bacterial Exacerbation of Chronic Bronchitis

Tab:
200mg q12h for 10 days

Gonorrhea

Uncomplicated Gonorrhea (Men and Women):
Single 200mg dose

Rectal Infections

Gonococcal Infections (Women):
Single 200mg dose

Skin and Skin Structure Infections

400mg q12h for 7-14 days

Acute Maxillary Sinusitis

200mg q12h for 10 days

Urinary Tract Infections

Uncomplicated:
100mg q12h for 7 days

PEDIATRIC DOSAGE

Acute Otitis Media

2 Months-12 Years:
Sus:

5mg/kg q12h for 5 days
Max: 200mg/dose

Tonsillitis and/or Pharyngitis

2 Months-12 Years:
Sus:
5mg/kg/dose q12h for 5-10 days
Max:
100mg/dose

≥12 Years:
100mg q12h for 5-10 days

Acute Maxillary Sinusitis

2 Months-12 Years:
Sus:
5mg/kg q12h for 10 days
Max:
200mg/dose

≥12 Years:
200mg q12h for 10 days

Community-Acquired Pneumonia

≥12 Years:
200mg q12h for 14 days

Gonorrhea

Uncomplicated (Men and Women):
≥12 Years:

Single 200mg dose

Rectal Infections

Gonococcal Infections (Women):
≥12 Years:
Single 200mg dose

Skin and Skin Structure Infections

≥12 Years:
400mg q12h for 7-14 days

Urinary Tract Infections

Uncomplicated:
≥12 Years:
100mg q12h for 7 days

Acute Bacterial Exacerbation of Chronic Bronchitis

≥12 Years:
200mg q12h for 10 days

DOSING CONSIDERATIONS

Renal Impairment
Severe (CrCl <30mL/min): Increase dosing interval to q24h
Hemodialysis: Dose 3X/week after hemodialysis

ADMINISTRATION

Oral route

Tab
Take w/ food

Sus
May be given w/o regard to food
Shake well before using

Preparation of Sus
50mL of 50mg/5mL: Suspend in 32mL of distilled water
100mL of 50mg/5mL: Suspend in 63mL of distilled water
50mL of 100mg/5mL: Suspend in 32mL of distilled water
100mL of 100mg/5mL: Suspend in 63mL of distilled water
Add water in approx 2 equal portions, shaking vigorously after each aliquot

HOW SUPPLIED

Sus: 50mg/5mL, 100mg/5mL [50mL, 100mL]; Tab: 100mg, 200mg

WARNINGS/PRECAUTIONS

Cross hypersensitivity among β-lactam antibiotics reported; caution in patients with penicillin (PCN) sensitivity. D/C if an allergic reaction occurs. Serious acute hypersensitivity reactions may require treatment with epinephrine and other emergency measures. Clostridium difficile-associated diarrhea (CDAD) reported; d/c if CDAD is suspected or confirmed. Pseudomembranous colitis reported. May result in bacterial resistance with prolonged use or in the absence of proven or suspected bacterial infection, or a prophylactic indication; take appropriate measures if superinfection develops. Lab test interactions may occur.

ADVERSE REACTIONS

Diarrhea, nausea.

DRUG INTERACTIONS

High doses of antacids (sodium bicarbonate and aluminum hydroxide) or H2 blockers reduce Cmax and the extent of absorption. Oral anticholinergics (eg, propantheline) delay Cmax. Probenecid inhibits renal excretion; monitor renal function with nephrotoxic agents. Caution with potent diuretics.

PREGNANCY AND LACTATION

Category B, not for use in nursing.

MECHANISM OF ACTION

Cephalosporin (3rd generation); bactericidal agent that acts by inhibition of bacterial cell-wall synthesis.

PHARMACOKINETICS

Absorption: (Tab) Cmax=1.4mcg/mL (100mg), 2.3mcg/mL (200mg), 3.9mcg/mL (400mg); Tmax=2-3 hrs. (Sus) Cmax=1.5mcg/mL (100mg). Distribution: Plasma protein binding (21-29%); found in breast milk. Metabolism: Via deesterification; cefpodoxime (active metabolite). Elimination: Urine (29-33% unchanged). (Tab) T1/2=2.09-2.84 hrs.

ASSESSMENT

Assess for history of hypersensitivity to cephalosporins, PCNs, or other drugs, renal impairment, pregnancy/nursing status, and possible drug interactions. Perform culture and susceptibility testing.

MONITORING

Monitor for signs/symptoms of hypersensitivity reactions, CDAD, pseudomembranous colitis, development of superinfection, and other adverse reactions.

PATIENT COUNSELING

Inform that therapy should only be used to treat bacterial, not viral (eg, common cold), infections. Instruct to take exactly ud even if the patient feels better early in the course of therapy. Inform that skipping doses or not completing the full course of therapy may decrease effectiveness of immediate treatment and increase bacterial resistance. Inform that diarrhea is a common problem caused by therapy, which usually ends when therapy is discontinued. Instruct to immediately contact physician if watery and bloody stools (with or without stomach cramps and fever) occur, even as late as ≥2 months after the last dose. (Sus) Inform that drug contains phenylalanine.

STORAGE

20-25°C (68-77°F). (Sus) After Constitution: 2-8°C (36-46°F). Discard unused portion after 14 days.

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