Buy Tinidazole Online

Tindamax (tinidazole)

BOXED WARNING

Carcinogenicity has been seen in mice and rats treated chronically with metronidazole. Although not reported for tinidazole, the two drugs are structurally related and have similar biologic effects. Use only for approved indications.

View FDA-Approved Full Prescribing Information for Tindamax

THERAPEUTIC CLASS

Antiprotozoal agent

DEA CLASS

RX

INDICATIONS

Treatment of trichomoniasis caused by Trichomonas vaginalis, giardiasis caused by Giardia duodenalis, intestinal amebiasis and amebic liver abscess caused by Entamoeba histolytica, and bacterial vaginosis in nonpregnant women.

ADULT DOSAGE

Trichomoniasis

Usual: 2g single dose

Sexual partners should be treated w/ the same dose at the same time

Giardiasis

Usual: 2g single dose taken w/ food

Amebiasis

Intestinal:
Usual: 2g/day for 3 days taken w/ food

Amebic Liver Abscess:
Usual: 2g/day for 3-5 days taken w/ food

Bacterial Vaginosis

In Nonpregnant Woman:
Usual: 2g qd for 2 days taken w/ food or 1g qd for 5 days taken w/ food

PEDIATRIC DOSAGE

Giardiasis

>3 Years:
Usual: 50mg/kg single dose taken w/ food
Max: 2g/day

Amebiasis

>3 Years:

Intestinal:

Usual: 50mg/kg/day for 3 days taken w/ food
Max: 2g/day

Amebic Liver Abscess:

Usual: 50mg/kg/day for 3-5 days taken w/ food; closely monitor when treatment duration is >3 days
Max: 2g/day

DOSING CONSIDERATIONS

Renal Impairment
Hemodialysis: If given on same day and prior to hemodialysis, give additional dose equivalent to 1/2 of recommended dose at the end of dialysis

ADMINISTRATION

Oral route

Take w/ food
Avoid alcoholic beverages when taking tinidazole and for 3 days afterwards
May crush tabs in artificial cherry syrup to be taken w/ food if unable to swallow whole tab; shake well before use

Pharmacy Compounding
Pulverize four 500mg tabs w/ a mortar and pestle
Add approx 10mL of cherry syrup to the powder and mix until smooth; transfer sus to a graduated amber container
Use small rinses of cherry syrup to transfer remaining drug to final sus for a final volume of 30mL

HOW SUPPLIED

Tab: 250mg*, 500mg* *scored

CONTRAINDICATIONS

Treatment during 1st trimester of pregnancy, nursing mothers during therapy and 3 days following last dose.

WARNINGS/PRECAUTIONS

Seizures, peripheral neuropathy reported. D/C if abnormal neurologic signs occur. Caution with hepatic impairment or blood dyscrasias. May develop vaginal candidiasis. May develop drug resistance if prescribed in absence of proven or strongly suspected bacterial infection. Caution in elderly.

ADVERSE REACTIONS

Metallic/bitter taste, N/V, vaginal fungal infection, anorexia, headache, dizziness, constipation, dyspepsia, cramps/epigastric discomfort, weakness, fatigue, malaise, convulsions, peripheral neuropathy.

DRUG INTERACTIONS

Avoid alcohol during therapy and for 3 days after use. Do not give if patient has taken disulfiram within the last 2 weeks. May potentiate oral anticoagulants. May prolong T1/2 and reduce clearance of phenytoin (IV). May decrease clearance of fluorouracil, causing increased side effects; if concomitant use needed, monitor for toxicities. May increase levels of lithium, cyclosporine, and tacrolimus. Separate dosing with cholestyramine. Phenobarbital, rifampin, phenytoin, fosphenytoin, and other CYP3A4 inducers may decrease levels. Cimetidine, ketoconazole, and other CYP3A4 inhibitors may increase levels. Therapeutic effect antagonized by oxytetracycline.

PREGNANCY AND LACTATION

Category C, not for use in nursing.

MECHANISM OF ACTION

Antiprotozoal, antibacterial agent; nitro group of tinidazole is reduced by cell extracts of Trichomonas. Free nitro radical generated as a result of this reduction may be responsible for antiprotozoal activity.

PHARMACOKINETICS

Absorption: Rapid, complete. (Fasted) Cmax=47.7mcg/mL, Tmax=1.6 hrs, AUC=901.6mcg.hr/mL at 72 hrs. Distribution: Vd=50L; plasma protein binding (12%); crosses blood-brain and placental barrier; found in breast milk. Metabolism: Mainly via oxidation, hydroxylation, conjugation; CYP3A4 mainly involved. Elimination: Urine (20-25% unchanged), feces (12%); T1/2=12-14 hrs.

ASSESSMENT

Assess for blood dyscrasias, seizures, pregnancy/nursing status, hypersensitivity and possible drug interactions. Assess for proven or strongly suspected bacterial infection to avoid drug resistance.

MONITORING

Monitor for convulsive seizures, peripheral neuropathy, vaginal candidiasis, drug resistance, hypersensitivity reactions (urticaria, pruritis, angioedema, erythema multiforme, Stevens-Johnson syndrome).

PATIENT COUNSELING

Advise to take with food to minimize epigastric discomfort and other GI side effects. Instruct to avoid alcohol and preparations containing ethanol and propylene glycol during therapy and for 3 days afterward to prevent abdominal cramps, N/V, headache, and flushing. Inform that therapy only treats bacterial, not viral (eg, common cold), infections. Instruct to take ud; skipping doses or not completing full course may decrease effectiveness and increase resistance.

STORAGE

20-25°C (68-77°F); excursions permitted to 15-30°C (59-86°F). Protect contents from light.

TAGS

generic tinidazole, buy cheap tinidazole, buy tinidazole no prescription, fasigyn tinidazole, tinidazole canada, ofloxacin tinidazole, tinidazole with out a prescription, tinidazole online, buy tinidazole from india online, tinidazole price, tinidazole pills for sale, norfloxacin and tinidazole, tinidazole shipped overnight delivery, metronidazole or tinidazole, tinidazole without prescription, ciprofloxacin tinidazole, buy tinidazole online, 1742 buy tinidazole 500mg, where to buy tinidazole, buy tinidazole for veterinary use, tinidazole dosage, where can i get tinidazole online, simplotan tinidazole side effects, tinidazole tablets 500mg, order tinidazole online, ciprofloxacin and tinidazole tablets, buy tinidazole 500mg, ciprofloxacin and tinidazole, tinidazole over the counter, tinidazole cheap without a prescription, tinidazole without perscription, tinidazole priscription, tinidazole dosage for dogs, ordering tinidazole, tinidazole tablets online, buy tinidazole in singapore, metronidazole or tinidazole without rx, tinidazole over the counter drug, can you get tinidazole over the counter, buy tinidazole, buy tinidazole without prescription, purchase tinidazole online, cheap tinidazole, tinidazole no prescription, metronidazole and tinidazole, tinidazole tindamax, what is tinidazole 500mg used for, tinidazole 1000 for ringworm, cipro tinidazole 500mg, tinidazole norfloxacin, norfloxacin with tinidazole, buying tinidazole, tinidazole 500mg, tinidazole cost, order tinidazole, norfloxacin tinidazole side effects, tinidazole giardia, tinidazole tablets, buy tinidazole usa, tinidazole for sale, tinidazole, tinidazole vs metronidazole, tinidazole for dogs, tinidazole metronidazole, tinidazole buy online aus