Buy Skelaxin Online

Skelaxin (metaxalone)

THERAPEUTIC CLASS

Muscular analgesic (centrally acting)

DEA CLASS

RX

INDICATIONS

Adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions.

ADULT DOSAGE

Musculoskeletal Pain

Relief of Discomforts Associated w/ Acute Conditions:
800mg tid-qid

PEDIATRIC DOSAGE

Musculoskeletal Pain

Relief of Discomforts Associated w/ Acute Conditions:
>12 Years:

800mg tid-qid

ADMINISTRATION

Oral route

Taking w/ food may enhance general CNS depression

HOW SUPPLIED

Tab: 800mg* *scored

CONTRAINDICATIONS

Known tendency to drug-induced, hemolytic, and other anemias. Significantly impaired renal/hepatic function.

WARNINGS/PRECAUTIONS

Caution with preexisting liver damage; perform serial LFTs. False (+) Benedict's tests reported; glucose-specific test will differentiate findings. Taking with food may enhance general CNS depression, especially in elderly patients.

ADVERSE REACTIONS

Drowsiness, dizziness, headache, nervousness, irritability, N/V, GI upset.

DRUG INTERACTIONS

Additive sedative effects with other CNS depressants (eg, alcohol, benzodiazepines, opioids, TCAs); use with caution if taking >1 CNS depressant simultaneously.

PREGNANCY AND LACTATION

Not for use in pregnancy/nursing.

MECHANISM OF ACTION

Muscular analgesic (central-acting); has not been established. Activity may be due to general depression of CNS.

PHARMACOKINETICS

Absorption: (400mg) Cmax=983ng/mL, Tmax=3.3 hrs; AUC=7479ng•hr/mL. (800mg) Cmax=1816ng/mL, Tmax=3 hrs; AUC=15,044ng•hr/mL. Distribution: Vd=800L. Metabolism: Liver; via CYP1A2, 2D6, 2E1, 3A4, and to a lesser extent CYP2C8, 2C9, C19. Elimination: Urine (metabolites); T1/2=9 hrs (400mg), 8 hrs (800mg).

ASSESSMENT

Assess for known tendency to drug-induced, hemolytic, or other anemias, significant renal/hepatic impairment, hypersensitivity to the drug, pregnancy/nursing status, and possible drug interactions.

MONITORING

Perform serial LFTs with preexisting liver damage. Monitor for signs/symptoms of CNS depression.

PATIENT COUNSELING

Inform that drug may impair mental and/or physical abilities required to perform hazardous tasks, especially when used with alcohol or other CNS depressants.

STORAGE

15-30°C (59-86°F).

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