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Robaxin (methocarbamol)


Robaxin Injection, Robaxin-750


Muscular analgesic (centrally acting)




Adjunct for relief of acute, painful musculoskeletal conditions.


Musculoskeletal Conditions

Adjunct for relief of discomfort associated w/ acute, painful musculoskeletal conditions

≥16 Years:
Initial: 3 tabs qid
Maint: 2 tabs qid

Initial: 2 tabs qid
Maint: 1 tab q4h or 2 tabs tid

6g/day are recommended for the first 48-72 hrs; 8g/day may be administered for severe conditions. Thereafter, the dose can usually be reduce to approx 4g/day

Moderate Symptoms:
Single 1g (10mL) dose IV/IM; administration of oral form will usually sustain relief initiated by the inj
Max: 3g/day for no more than 3 consecutive days

Severe Cases/Postop Conditions:
Single 1g (10mL) dose IV/IM; may administer additional doses of 1g q8h
Max: 3g/day for no more than 3 consecutive days


1 or 2 vials directly into the tubing of the previously inserted indwelling needle; additional 10mL or 20mL may be added to infusion bottle so that a total of up to 30mL (3 vials) is given as initial dose

Repeat q6h until conditions allow for insertion of NG tube; crushed methocarbamol tabs suspended in water or saline may then be given through this tube

Total oral doses up to 24g/day may be required



Initial: 15mg/kg or 500mg/m2; repeat q6h prn
Max: 1.8g/m2 for 3 consecutive days

Maint dose may be administered by inj into tubing or by IV infusion w/ an appropriate quantity of fluid


Oral/IV/IM route

Directions for IV Use
Inj may be administered undiluted at a max rate of 3mL/min or added to an IV drip of NaCl inj or D5 inj
One vial given as a single dose should not be diluted to more than 250mL for IV infusion
Do not refrigerate after mixing w/ IV infusion fluids
Avoid vascular extravasation of this hypertonic sol, which may result in thrombophlebitis
Patient should be in a recumbent position during and for at least 10-15 min following inj

Directions for IM Use
Not more than 5mL (1/2 vial) should be injected into each gluteal region
Inj may be repeated at 8-hr intervals, if necessary
When satisfactory relief of symptoms is achieved, it can usually be maintained w/ tabs
Not recommended for SQ administration


Inj: 100mg/mL [10mL]; Tab: 500mg, 750mg


(Inj) Renal pathology with injection due to propylene glycol content.


May impair mental/physical abilities. May cause color interference in certain screening tests for 5-hydroxy-indoleacetic acid (5-HIAA) and vanillylmandelic acid (VMA). Caution in epilepsy with the inj. Inj rate should not exceed 3mL/min. Avoid extravasation with inj. Avoid use in women who are or may become pregnant and particularly during early pregnancy.


Lightheadedness, dizziness, drowsiness, nausea, urticaria, pruritus, rash, conjunctivitis, nasal congestion, blurred vision, headache, fever, seizures, syncope, flushing.


Additive adverse effects with alcohol and other CNS depressants. May inhibit effect of pyridostigmine; caution in patients with myasthenia gravis receiving anticholinergics.


Category C, caution in nursing.


Carbamate derivative of guaifenesin; not established, suspected to have CNS depressant with sedative and musculoskeletal relaxant properties.


Distribution: Plasma protein binding (46-50%). Found in breast milk. Metabolism: Via dealkylation, hydroxylation, and conjugation pathways. Elimination: Urine; T1/2=1-2 hrs.


Assess for renal/hepatic impairment, myasthenia gravis, seizures, pregnancy/nursing status, alcohol intake, and drug interactions.


Monitor for congenital and fetal abnormalities if taken during pregnancy, for color interference in certain screening tests for 5-HIAA using nitrosonaphthol reagent, and in screening tests for urinary VMA using Gitlow method.


Instruct to use caution while performing hazardous tasks. Warn to avoid alcohol or other CNS depressants. Instruct to notify physician if pregnant/nursing or if planning to become pregnant.


20-25°C (68-77°F), in tight container; excursions permitted to 15-30°C (59-86°F).


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