Buy Omnicef Online

Cefdinir (cefdinir)

OTHER BRAND NAMES

Omnicef (Discontinued)

THERAPEUTIC CLASS

Cephalosporin (3rd generation)

DEA CLASS

RX

INDICATIONS

Community-acquired pneumonia (CAP), acute exacerbations of chronic bronchitis (AECB), acute maxillary sinusitis, pharyngitis/tonsillitis, and uncomplicated skin and skin structure infections (SSSIs) in adult and adolescent patients. Acute bacterial otitis media, pharyngitis/tonsillitis, and uncomplicated SSSIs in pediatric patients.

ADULT DOSAGE

Community-Acquired Pneumonia

Cap:
300mg q12h for 10 days

Acute Bacterial Exacerbation of Chronic Bronchitis

Cap:
300mg q12h for 5-10 days or 600mg q24h for 10 days

Acute Maxillary Sinusitis

Cap:
300mg q12h or 600mg q24h for 10 days

Pharyngitis/Tonsillitis

Cap:
300mg q12h for 5-10 days or 600mg q24h for 10 days

Skin and Skin Structure Infections

Uncomplicated:
Cap:
300mg q12h for 10 days

PEDIATRIC DOSAGE

Skin and Skin Structure Infections

Uncomplicated:
Sus:
6 Months-12 Years:
7mg/kg q12h for 10 days
≥43kg: 600mg/day
Max: 600mg/day

Cap:
≥13 Years:
300mg q12h for 10 days

Acute Otitis Media

Sus:
6 Months-12 Years:
7mg/kg q12h for 5-10 days or 14mg/kg q24h for 10 days
≥43kg: 600mg/day
Max: 600mg/day

Community-Acquired Pneumonia

Cap:
≥13 Years:

300mg q12h for 10 days

Acute Bacterial Exacerbation of Chronic Bronchitis

Cap:
≥13 Years:

300mg q12h for 5-10 days or 600mg q24h for 10 days

Acute Maxillary Sinusitis

Sus:
6 Months-12 Years:
7mg/kg q12h or 14mg/kg q24h for 10 days
≥43kg: 600mg/day
Max: 600mg/day

Cap:
≥13 Years:
300mg q12h or 600mg q24h for 10 days

Pharyngitis/Tonsillitis

Sus:
6 Months-12 Years:
7mg/kg q12h for 5-10 days or 14mg/kg q24h for 10 days
≥43kg: 600mg/day
Max: 600mg/day

Cap:
≥13 Years:
300mg q12h for 5-10 days or 600mg q24h for 10 days

DOSING CONSIDERATIONS

Renal Impairment
Adults:
CrCl <30mL/min: 300mg qd
Hemodialysis:
Initial: 300mg or 7mg/kg qod; give 300mg or 7mg/kg at the end of each hemodialysis session
Usual: 300mg or 7mg/kg qod

Pediatrics:
CrCl <30mL/min/1.73m2: 7mg/kg qd
Max: 300mg qd
Hemodialysis:
Initial: 300mg or 7mg/kg qod; give 300mg or 7mg/kg at the end of each hemodialysis session
Usual: 300mg or 7mg/kg qod

ADMINISTRATION

Oral route

Take without regard to food

Sus
Shake well before use
Reconstitute with 37mL of water (final volume of 60mL) or add 62mL of water (final volume of 100mL); add water in 2 portions, shake well after each aliquot

HOW SUPPLIED

Cap: 300mg; Sus: 125mg/5mL, 250mg/5mL [60mL, 100mL]

WARNINGS/PRECAUTIONS

Caution in penicillin-sensitive patients; cross-hypersensitivity among β-lactam antibiotics may occur. D/C use if an allergic reaction occurs. Serious acute hypersensitivity reactions may require the use of SQ epinephrine and other emergency measures. Clostridium difficile-associated diarrhea (CDAD) reported. May result in bacterial resistance with prolonged use in the absence of a proven or suspected bacterial infection, or a prophylactic indication; take appropriate measures if superinfection develops. Reduce dose in patients with transient or persistent renal insufficiency (CrCl <30mL/min). Caution in patients with a history of colitis. Lab test interaction may occur.

ADVERSE REACTIONS

Diarrhea, vaginal moniliasis, nausea, rash.

DRUG INTERACTIONS

Iron-fortified foods (except iron-fortified infant formula), iron supplements, and aluminum- or magnesium-containing antacids reduce absorption; take dose at least 2 hrs before or after these medications. Inhibited renal excretion with probenecid. Reddish stools reported with iron-containing products. Possible interaction with diclofenac reported.

PREGNANCY AND LACTATION

Category B, safe in nursing.

MECHANISM OF ACTION

Cephalosporin (3rd generation); bactericidal activity results from its inhibition of cell-wall synthesis.

PHARMACOKINETICS

Absorption: Cap: (300mg) Cmax=1.60mcg/mL, Tmax=2.9 hrs, AUC=7.05mcg•hr/mL. (600mg) Cmax=2.87mcg/mL, Tmax=3 hrs, AUC=11.1mcg•hr/mL. Sus: (7mg/kg) Cmax=2.30mcg/mL, Tmax=2.2 hrs, AUC=8.31mcg•hr/mL. (14mg/kg) Cmax=3.86mcg/mL, Tmax=1.8 hrs, AUC=13.4mcg•hr/mL. Distribution: Vd=0.35L/kg (adults), 0.67L/kg (pediatrics); plasma protein binding (60-70%). Elimination: (300mg) Urine (18.4% unchanged); (600mg) Urine (11.6% unchanged); T1/2=1.7 hrs.

ASSESSMENT

Assess for allergy to other cephalosporins, PCN, or to other drugs, history of colitis, renal impairment, and for possible drug interactions. Assess for diabetes if planning to use sus formulation.

MONITORING

Monitor for signs/symptoms of hypersensitivity reactions, CDAD, and development of superinfection.

PATIENT COUNSELING

Inform that therapy only treats bacterial, not viral, infections. Instruct to take ud; skipping doses or not completing full course may decrease drug effectiveness and increase risk of bacterial resistance. Instruct to take dose at least 2 hrs before or after antacid or iron supplements. Inform diabetic patients and caregivers that sus contains 2.86g of sucrose/tsp. Inform that diarrhea (watery/bloody stools) may be experienced as late as 2 months or more after last dose and instruct to contact physician as soon as possible if this occurs.

STORAGE

Cap: 25°C (77°F); excursions permitted to 15-30°C (59-86°F). Unsuspended Powder: 20-25°C (68-77°F). Reconstituted Sus: Can be stored at controlled room temperature for 10 days.

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