Buy Myambutol Online

Myambutol (ethambutol hydrochloride)

THERAPEUTIC CLASS

Cell metabolism inhibitor

DEA CLASS

RX

INDICATIONS

Treatment of pulmonary tuberculosis in conjunction with at least 1 other antituberculous drug.

ADULT DOSAGE

Tuberculosis

Treatment of pulmonary tuberculosis in conjunction w/ at least 1 other antituberculous drug

Initial Treatment:
15mg/kg (7mg/lb) as a single dose q24h, in patients who have not received previous antituberculous therapy

Retreatment:
25mg/kg (11mg/lb) as a single dose q24h; after 60 days of therapy, decrease to 15mg/kg (7mg/lb) as a single dose q24h

Easy Selection of Proper Weight-Dose Tab:
15mg/kg Schedule:
<37kg: 500mg
37-43kg: 600mg
43-50kg: 700mg
50-57kg: 800mg
57-64kg: 900mg
64-71kg: 1000mg
71-79kg: 1100mg
79-84kg: 1200mg
84-90kg: 1300mg
90-97kg: 1400mg
>97kg: 1500mg

25mg/kg Schedule:
<38kg: 900mg
38-42kg: 1000mg
42-45.5kg: 1100mg
45.5-50kg: 1200mg
50-54kg: 1300mg
54-58kg: 1400mg
58-62kg: 1500mg
62-67kg: 1600mg
67-71kg: 1700mg
71-75kg: 1800mg
75-79kg: 1900mg
79-83kg: 2000mg
83-87kg: 2100mg
87-91kg: 2200mg
91-95kg: 2300mg
95-99kg: 2400mg
>95kg: 2500mg

Continue until bacteriological conversion has become permanent and maximal clinical improvement has occurred

PEDIATRIC DOSAGE

Tuberculosis

Treatment of pulmonary tuberculosis in conjunction w/ at least 1 other antituberculous drug

≥13 Years:
Initial Treatment:

15mg/kg (7mg/lb) as a single dose q24h, in patients who have not received previous antituberculous therapy

Retreatment:
25mg/kg (11mg/lb) as a single dose q24h; after 60 days of therapy, decrease to 15mg/kg (7mg/lb) as a single dose q24h

Easy Selection of Proper Weight-Dose Tab:
15mg/kg Schedule:
<37kg: 500mg
37-43kg: 600mg
43-50kg: 700mg
50-57kg: 800mg
57-64kg: 900mg
64-71kg: 1000mg
71-79kg: 1100mg
79-84kg: 1200mg
84-90kg: 1300mg
90-97kg: 1400mg
>97kg: 1500mg

25mg/kg Schedule:
<38kg: 900mg
38-42kg: 1000mg
42-45.5kg: 1100mg
45.5-50kg: 1200mg
50-54kg: 1300mg
54-58kg: 1400mg
58-62kg: 1500mg
62-67kg: 1600mg
67-71kg: 1700mg
71-75kg: 1800mg
75-79kg: 1900mg
79-83kg: 2000mg
83-87kg: 2100mg
87-91kg: 2200mg
91-95kg: 2300mg
95-99kg: 2400mg
>95kg: 2500mg

Continue until bacteriological conversion has become permanent and maximal clinical improvement has occurred

DOSING CONSIDERATIONS

Renal Impairment
Renal Dysfunction: Reduce dose as determined by serum levels of treatment

ADMINISTRATION

Oral route

HOW SUPPLIED

Tab: 100mg, 400mg* *scored

CONTRAINDICATIONS

Known optic neuritis, inability to appreciate and report visual side effects or changes in vision (eg, young children, unconscious patients).

WARNINGS/PRECAUTIONS

May produce decreases in visual acuity due to optic neuritis; may be related to dose and duration of treatment, and is generally reversible upon prompt discontinuation. Irreversible blindness has been reported. Liver toxicities including fatalities reported; perform baseline and periodic hepatic function assessment. Caution with cataracts, recurrent inflammatory eye conditions, optic neuritis, and diabetic retinopathy. Perform visual acuity testing before and periodically during therapy. Perform monthly visual acuity testing with >15mg/kg/day dose. Monthly eye examinations are advised with 25mg/kg/day dose.

ADVERSE REACTIONS

Optic neuropathy, anaphylactic reactions, dermatitis, pruritus, joint pain, N/V, malaise, dizziness, mental confusion, elevated uric acid levels, pulmonary infiltrates, thrombocytopenia, leukopenia, neutropenia.

DRUG INTERACTIONS

Aluminum hydroxide-containing antacids may reduce oral absorption; avoid aluminum hydroxide-containing antacids for at least 4 hrs following ethambutol administration.

PREGNANCY AND LACTATION

Category C, caution in nursing.

MECHANISM OF ACTION

Cell metabolism inhibitor; inhibits synthesis of 1 or more metabolites, thus causing impairment of cell metabolism, arrest of multiplication, and cell death.

PHARMACOKINETICS

Absorption: (25mg/kg dose) Cmax=2-5mcg/mL; Tmax=2-4 hrs. Distribution: Found in breast milk. Metabolism: Initial oxidation of the alcohol to an aldehydic intermediate, followed by conversion to a dicarboxylic acid. Elimination: Urine (50% unchanged, 8-15% metabolites), feces (20-22% unchanged).

ASSESSMENT

Assess for known optic neuritis, inability to appreciate and report visual side effects/changes, visual defects, hepatic/renal/hematopoietic function, pregnancy/nursing status, and possible drug interaction. Perform physical examination including ophthalmoscopy, finger perimetry, and testing of color discrimination and visual acuity.

MONITORING

Perform periodic eye examination and monitoring of hepatic/renal/hematopoietic function. Perform monthly visual acuity testing with >15mg/kg/day dose, and monthly eye examination with 25mg/kg/day dose.

PATIENT COUNSELING

Advise to report promptly to physician any change of visual acuity. Counsel about side effects and inform to seek prompt medical attention if any signs/symptoms of adverse effects develop.

STORAGE

20-25°C (68-77°F).

TAGS

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