Buy Meclizine Online

Antivert (meclizine hydrochloride)

THERAPEUTIC CLASS

Antihistamine

DEA CLASS

RX

INDICATIONS

Management of N/V, and dizziness associated with motion sickness. Management of vertigo associated with diseases affecting the vestibular system.

ADULT DOSAGE

Motion Sickness

25-50mg 1 hr prior to embarkation
Thereafter, may repeat dose q24h for the duration of the journey

Vertigo

25-100mg/day in divided doses, depending upon clinical response

PEDIATRIC DOSAGE

Motion Sickness

≥12 Years:
25-50mg 1 hr prior to embarkation
Thereafter, may repeat dose q24h for the duration of the journey

Vertigo

≥12 Years:
25-100mg/day in divided doses, depending upon clinical response

ADMINISTRATION

Oral route

HOW SUPPLIED

Tab: 12.5mg, 25mg, 50mg

WARNINGS/PRECAUTIONS

Caution with asthma, glaucoma, enlargement of the prostate gland, hepatic/renal impairment, and in elderly. Drowsiness may occur. May impair physical/mental abilities.

ADVERSE REACTIONS

Anaphylactoid reaction, drowsiness, dry mouth, headache, fatigue, vomiting.

DRUG INTERACTIONS

Avoid alcohol use. Increased CNS depression with other CNS depressants (eg, alcohol, tranquilizers, sedatives). Possible interaction with CYP2D6 inhibitors.

PREGNANCY AND LACTATION

Category B, caution in nursing.

MECHANISM OF ACTION

Antihistamine; has marked effect in blocking the vasodepressor response to histamine, but only a slight blocking action against acetylcholine.

PHARMACOKINETICS

Absorption: Tmax=3 hrs. Metabolism: Via CYP2D6. Elimination: T1/2=5-6 hrs.

ASSESSMENT

Assess for previous hypersensitivity to the drug, asthma, glaucoma, prostate gland enlargement, renal/hepatic impairment, pregnancy/nursing status, and possible drug interactions.

MONITORING

Monitor for drowsiness and other adverse reactions.

PATIENT COUNSELING

Inform that drowsiness may occur; instruct to use caution when driving a vehicle or operating machinery. Advise to avoid alcohol use. Advise to notify physician if pregnant/nursing.

STORAGE

<30°C (86°F).

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