Buy Lincocin Online

Lincocin (lincomycin hydrochloride)

BOXED WARNING

Clostridium difficile-associated diarrhea (CDAD) reported; may need to d/c if CDAD is suspected or confirmed. Associated w/ severe colitis; reserve for serious infections where less toxic antimicrobials are inappropriate. Do not use in patients w/ nonbacterial infections, such as most URTIs.

THERAPEUTIC CLASS

Streptomyces lincolnensis derivative

DEA CLASS

RX

INDICATIONS

Treatment of serious infections due to susceptible strains of streptococci, pneumococci, and staphylococci.

ADULT DOSAGE

Serious Infections

Due to Susceptible Strains of Streptococci, Pneumococci, and Staphylococci:
IM:
600mg (2mL) q24h
More Severe Infections: 600mg q12h or more often

IV:
600mg-1g q8-12h
More Severe Infections: May have to increase dose; in life-threatening situations, doses of as much as 8g/day have been given
Max: 8g/day

Subconjunctival Inj:
0.25mL (75mg) will result in ocular fluid levels of antibacterial (lasting for at least 5 hrs) w/ minimum inhibitory concentrations sufficient for most susceptible pathogens

PEDIATRIC DOSAGE

Serious Infections

Due to Susceptible Strains of Streptococci, Pneumococci, and Staphylococci:
>1 Month of Age:

IM:
One inj of 10mg/kg (5mg/lb) q24h
More Severe Infections:
One inj of 10mg/kg q12h or more often

IV:
10-20mg/kg/day depending on the severity of the infection; may be infused in divided doses as described for adults

DOSING CONSIDERATIONS

Renal Impairment
Severe Impairment: 25-30% of that recommended for patients w/ normal renal function

ADMINISTRATION

IM/IV/Subconjunctival route

IV
IV doses are given on the basis of 1g of therapy diluted in not <100mL of appropriate sol and infused over a period of not <1 hr
Dilute 600mg or 1g dose w/ 100mL of compatible diluent and infuse for 1 hr
Dilute 2g dose w/ 200mL of compatible diluent and infuse for 2 hrs
Dilute 3g dose w/ 300mL of compatible diluent and infuse for 3 hrs
Dilute 4g dose w/ 400mL of compatible diluent and infuse for 4 hrs
Do not inject IV undiluted as a bolus

Compatible Infusion Sol
D5 inj
D10 inj
D5 and 0.9% NaCl inj
D10 and 0.9% NaCl inj
Ringer's inj
1/6 M sodium lactate inj
Travert 10%-Electrolyte No. 1
Dextran in saline 6% w/v

HOW SUPPLIED

Inj: 300mg/mL [2mL, 10mL]

WARNINGS/PRECAUTIONS

Severe cardiopulmonary reactions reported when given at greater than the recommended concentration and rate. Serious hypersensitivity reactions (eg, anaphylaxis, erythema multiforme) reported; d/c if an allergic reaction occurs. Contains benzyl alcohol, which has been associated w/ serious adverse events, including the gasping syndrome, and death in pediatric patients; more likely to develop toxicity in premature and low-birth weight infants. May be inadequate for meningitis treatment. Caution w/ history of GI disease (particularly colitis), asthma, or significant allergies. May result in bacterial resistance if used in the absence of proven or suspected bacterial infection, or if used in a prophylactic indication; take appropriate measures if superinfection develops. Caution w/ abnormal hepatic function.

ADVERSE REACTIONS

CDAD, persistent diarrhea.

DRUG INTERACTIONS

May enhance action of neuromuscular blocking agents; use w/ caution. Antagonism between therapy and erythromycin reported; do not administer concurrently.

PREGNANCY AND LACTATION

Category C, not for use in nursing.

MECHANISM OF ACTION

Streptomyces lincolnensis derivative; possesses antibacterial activity.

PHARMACOKINETICS

Absorption: (600mg, IM) Cmax=11.6mcg/mL; Tmax=60 min. (600mg, IV) Cmax=15.9mcg/mL. Distribution: Found in breast milk. Elimination: Bile, urine (17.3% [IM]; 13.8% [IV]); T1/2=5.4 hrs (IM/IV).

ASSESSMENT

Assess for hypersensitivity to drug or clindamycin, history of GI disease, asthma, or significant allergies, renal/hepatic impairment, pregnancy/nursing status, and possible drug interactions. Perform culture and susceptibility testing.

MONITORING

Monitor for signs/symptoms of CDAD, allergic reaction, superinfection, and other adverse reactions. Carefully monitor elderly w/ associated severe illness for change in bowel frequency. Perform periodic LFTs, renal function tests, blood counts, and serum lincomycin levels during prolonged or high-dose therapy.

PATIENT COUNSELING

Inform that therapy should only be used to treat bacterial, not viral (eg, common cold), infections. Instruct to take exactly ud even if the patient feels better early in the course of therapy. Inform that skipping doses or not completing full course of therapy may decrease effectiveness of immediate treatment and increase bacterial resistance. Inform that diarrhea is a common problem caused by therapy, which usually ends when therapy is discontinued. Instruct to immediately contact physician if watery and bloody stools (w/ or w/o stomach cramps and fever) occur, even as late as ≥2 months after the last dose.

STORAGE

20-25°C (68-77°F).

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