Buy Famvir Online

Famvir (famciclovir)

THERAPEUTIC CLASS

Nucleoside analogue

DEA CLASS

RX

INDICATIONS

Treatment of herpes zoster (shingles) and recurrent herpes labialis (cold sores) in immunocompetent adults. Treatment and chronic suppressive therapy of recurrent episodes of genital herpes in immunocompetent adults. Treatment of recurrent episodes of orolabial or genital herpes in HIV-infected adults.

ADULT DOSAGE

Herpes Zoster

500mg q8h for 7 days
Initiate as soon as diagnosed

Herpes

Orolabial/Genital:
Recurrent in HIV-Infected Patients:
500mg bid for 7 days
Initiate at 1st sign/symptom

Herpes Labialis (Cold Sores)

Recurrent:
1500mg single dose
Initiate at 1st sign/symptom

Genital Herpes

Recurrent Episodes:
1000mg bid for 1 day
Initiate at 1st sign/symptom

Suppressive Therapy:
250mg bid

DOSING CONSIDERATIONS

Renal Impairment
Recurrent Herpes Labialis:
CrCl 40-59mL/min: 750mg single dose
CrCl 20-39mL/min: 500mg single dose
CrCl <20mL/min: 250mg single dose
Hemodialysis: 250mg single dose following dialysis

Recurrent Genital Herpes:
CrCl 40-59mL/min: 500mg q12h for 1 day
CrCl 20-39mL/min: 500mg single dose
CrCl <20mL/min: 250mg single dose
Hemodialysis: 250mg single dose following dialysis

Suppression of Recurrent Genital Herpes:
CrCl 20-39mL/min: 125mg q12h
CrCl <20mL/min: 125mg q24h
Hemodialysis: 125mg following each dialysis

Herpes Zoster:
CrCl 40-59mL/min: 500mg q12h
CrCl 20-39mL/min: 500mg q24h
CrCl <20mL/min: 250mg q24h
Hemodialysis: 250mg following each dialysis

Recurrent Orolabial/Genital Herpes in HIV-Infected Patients:
CrCl 20-39mL/min: 500mg q24h
CrCl <20mL/min: 250mg q24h
Hemodialysis: 250mg following each dialysis

ADMINISTRATION

Oral route
Take w/ or w/o food

HOW SUPPLIED

Tab: 125mg, 250mg, 500mg

WARNINGS/PRECAUTIONS

Acute renal failure reported in patients with underlying renal disease who have received inappropriately high doses. Caution in elderly and with renal impairment.

ADVERSE REACTIONS

Headache, N/V, diarrhea, elevated lipase, ALT elevation, fatigue, flatulence, pruritus, rash, neutropenia, abdominal pain, dysmenorrhea, migraine.

DRUG INTERACTIONS

Probenecid or other drugs significantly eliminated by active renal tubular secretion may increase levels of penciclovir. Potential interaction with drugs metabolized by and/or inhibiting aldehyde oxidase. Raloxifene may decrease formation of penciclovir.

PREGNANCY AND LACTATION

Category B, not for use in nursing.

MECHANISM OF ACTION

Nucleoside analogue; prodrug of penciclovir, which has demonstrated inhibitory activity against herpes simplex virus types 1 and 2 and varicella zoster virus.

PHARMACOKINETICS

Absorption: Penciclovir: Absolute bioavailability (77%). Oral administration of variable doses resulted in different parameters. Distribution: Penciclovir: (IV) Vd=1.08L/kg; plasma protein binding (<20%). Metabolism: Deacetylation and oxidation; famciclovir (prodrug) converted to penciclovir. Elimination: Urine (73%, 82% penciclovir, 7% 6-deoxy penciclovir), feces (27%); T1/2=2.8 hrs (single dose, herpes zoster patients), 2.7 hrs (repeated doses, herpes zoster patients).

ASSESSMENT

Assess for hypersensitivity to the drug, renal impairment, pregnancy/nursing status, and possible drug interactions.

MONITORING

Monitor renal function and for adverse reactions.

PATIENT COUNSELING

Inform to take exactly ud. Advise to initiate treatment at earliest signs/symptoms of recurrence of cold sores, at the 1st sign/symptom of recurrent genital herpes if episodic therapy is indicated, and as soon as possible after a diagnosis of herpes zoster. Inform that drug is not a cure for cold sores or genital herpes. Advise to avoid contact with lesions or intercourse when lesions and/or symptoms are present to avoid infecting partners. Counsel to use safer sex practices. Instruct to refrain from driving or operating machinery if dizziness, somnolence, confusion, or other CNS disturbances occur. Inform that drug contains lactose; instruct to notify physician if with rare hereditary problems of galactose intolerance, a severe lactase deficiency, or glucose-galactose malabsorption.

STORAGE

25°C (77°F); excursions permitted to 15-30°C (59-86°F).

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