Buy Duricef Online

Cefadroxil (cefadroxil)

OTHER BRAND NAMES

Duricef (Discontinued)

THERAPEUTIC CLASS

Cephalosporin (1st generation)

DEA CLASS

RX

INDICATIONS

Treatment of urinary tract infections (UTIs), skin and skin structure infections (SSSIs), and pharyngitis and/or tonsillitis caused by susceptible strains of microorganisms.

ADULT DOSAGE

Urinary Tract Infections

Uncomplicated Lower UTIs (eg, Cystitis):
Usual: 1 or 2g/day given qd or bid

Other UTIs:
Usual: 2g/day given bid

Skin and Skin Structure Infections

Usual: 1g/day given qd or bid

Tonsillitis and/or Pharyngitis

Caused by Group A β-Hemolytic Streptococci:
1g/day given qd or bid for 10 days

PEDIATRIC DOSAGE

Urinary Tract Infections

Usual: 30mg/kg/day in divided doses q12h

Skin and Skin Structure Infections

Impetigo:
Usual: 30mg/kg/day given qd or in equally divided doses q12h

Other SSSIs:
Usual: 30mg/kg/day in divided doses q12h

Tonsillitis and/or Pharyngitis

Usual: 30mg/kg/day given qd or in equally divided doses q12h

Streptococcal Infections

β-Hemolytic Infections:
Administer for at least 10 days

DOSING CONSIDERATIONS

Renal Impairment
Adults:
Initial: 1g
Maint:
CrCl 25-50mL/min: 500mg q12h
CrCl 10-25mL/min: 500mg q24h
CrCl 0-10mL/min: 500mg q36h

ADMINISTRATION

Oral route

Take w/o regard to meals

Sus
Suspend 50mL bottle size in a total of 34mL water, 75mL bottle size in a total of 51mL water, 100mL bottle size in a total of 67mL water; add water in two portions and shake well after each addition
Shake well before using

Refer to PI for daily dosage of oral sus

HOW SUPPLIED

Cap: 500mg; Sus: 250mg/5mL [50mL, 100mL], 500mg/5mL [50mL, 75mL, 100mL]; Tab: 1000mg* *scored

WARNINGS/PRECAUTIONS

Caution in penicillin (PCN)-sensitive patients; cross-sensitivity among β-lactam antibiotics may occur. D/C if an allergic reaction occurs. Clostridium difficile-associated diarrhea (CDAD) reported; may need to d/c if CDAD is suspected or confirmed. Caution w/ renal impairment (CrCl <50mL/min); monitor prior to and during therapy. May result in bacterial resistance if used in the absence of proven or suspected bacterial infection, or a prophylactic indication. May result in overgrowth of nonsusceptible organisms w/ prolonged use; take appropriate measures if superinfection develops. Caution w/ history of GI disease, particularly colitis. Lab test interactions may occur. D/C if seizures associated w/ drug therapy occur. Caution in elderly.

ADVERSE REACTIONS

Diarrhea, allergies, hepatic dysfunction, genital moniliasis, vaginitis, moderate transient neutropenia, fever, toxic epidermal necrolysis, abdominal pain, superinfection, renal dysfunction, toxic nephropathy, aplastic anemia, hemolytic anemia, hemorrhage.

PREGNANCY AND LACTATION

Category B, caution in nursing.

MECHANISM OF ACTION

Cephalosporin (1st generation); bactericidal activity results from its inhibition of cell-wall synthesis.

PHARMACOKINETICS

Absorption: Rapid. Cmax=16mcg/mL (500mg), 28mcg/mL (1000mg). Elimination: Urine (>90% unchanged).

ASSESSMENT

Assess for allergy to other cephalosporins, PCN, or to other drugs, renal impairment, history of GI disease, and pregnancy/nursing status. Initiate culture and susceptibility tests prior to therapy.

MONITORING

Monitor for signs/symptoms of an allergic reaction, CDAD, seizure, and superinfection. Carefully observe patients w/ known or suspected renal impairment.

PATIENT COUNSELING

Inform that therapy only treats bacterial, not viral, infections. Instruct to take exactly ud; inform that skipping doses or not completing full course of therapy may decrease effectiveness and increase risk of bacterial resistance. Inform that diarrhea is a common problem that usually ends upon discontinuation. Instruct to notify physician as soon as possible if watery and bloody stools (w/ or w/o stomach cramps/fever) occur, even as late as ≥2 months after last dose.

STORAGE

(Cap/Tab) 20-25°C (68-77°F). (Sus) Before Reconstitution: 25°C (77°F); excursions permitted to 15-30°C (59-86°F). After Reconstitution: Store in refrigerator; discard unused portion after 14 days.

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