Buy Clarinex Online

Desloratadine (desloratadine)

OTHER BRAND NAMES

Clarinex

THERAPEUTIC CLASS

H1 antagonist

DEA CLASS

RX

INDICATIONS

Relief of nasal and non-nasal symptoms of seasonal allergic rhinitis in patients ≥2 yrs of age. Relief of nasal and non-nasal symptoms of perennial allergic rhinitis in patients ≥6 months of age. (Clarinex) Symptomatic relief of pruritus and reduction in number and size of hives in patients ≥6 months of age with chronic idiopathic urticaria.

ADULT DOSAGE

Seasonal Allergic Rhinitis

Relief of Nasal and Non-Nasal Symptoms:
Usual: 5mg or 10mL qd

Perennial Allergic Rhinitis

Relief of Nasal and Non-Nasal Symptoms:
Usual: 5mg or 10mL qd

Chronic Idiopathic Urticaria

Clarinex Tab/Sol:
Relief of pruritus and reduction in number/size of hives

Usual: 5mg or 10mL qd

PEDIATRIC DOSAGE

Seasonal Allergic Rhinitis

Relief of Nasal and Non-Nasal Symptoms:
2-5 Years:
2.5mL qd

6-11 Years:
2.5mg or 5mL qd

≥12 Years:
5mg or 10mL qd

Perennial Allergic Rhinitis

Relief of Nasal And Non-Nasal Symptoms:
6-11 Months of Age:
2mL qd

12 Months-5 Years:
2.5mL qd

6-11 Years:
2.5mg or 5mL qd

≥12 Years:
5mg or 10mL qd

Chronic Idiopathic Urticaria

Clarinex Tab/Sol:
Relief of pruritus and reduction in number/size of hives

6-11 Months of Age:
2mL qd

12 Months-5 Years:
2.5mL qd

6-11 Years:
2.5mg or 5mL qd

≥12 Years:
5mg or 10mL qd

DOSING CONSIDERATIONS

Renal Impairment
Adults:
Initial: 5mg qod

Hepatic Impairment
Adults:
Initial: 5mg qod

ADMINISTRATION

Oral route

May take w/o regard to meals

Sol
Administer w/ a measuring dropper or syringe calibrated to deliver 2mL and 2.5mL

Tab, Disintegrating
Place on tongue and allow to disintegrate before swallowing
Take immediately after opening the blister
Administer w/ or w/o water

HOW SUPPLIED

Tab, Disintegrating: 2.5mg, 5mg; (Clarinex) Sol: 0.5mg/mL [4 oz, 16 oz]; Tab: 5mg

WARNINGS/PRECAUTIONS

Hypersensitivity reactions reported; d/c therapy if any occur and consider alternative treatment. Caution in elderly.

ADVERSE REACTIONS

Pharyngitis, dry mouth, headache, N/V, fatigue, myalgia, fever, diarrhea, cough, URTI, irritability, somnolence, bronchitis, otitis media, dizziness.

DRUG INTERACTIONS

CYP450 3A4 inhibitors (eg, ketoconazole, erythromycin, azithromycin), fluoxetine, and cimetidine may increase levels.

PREGNANCY AND LACTATION

Category C, not for use in nursing.

MECHANISM OF ACTION

H1-receptor antagonist; inhibits histamine release from human mast cells in vitro.

PHARMACOKINETICS

Absorption: (5mg tab) Tmax=3 hrs, Cmax=4ng/mL, AUC=56.9ng•hr/mL. Distribution: Plasma protein binding (82-87%, 85-89% active metabolite); found in breast milk. Metabolism: Extensive; glucuronidation; 3-hydroxydesloratadine (active metabolite). Elimination: Urine and feces (87%); T1/2=27 hrs.

ASSESSMENT

Assess for hypersensitivity to drug, renal/hepatic impairment, pregnancy/nursing status, and possible drug interactions.

MONITORING

Monitor for hypersensitivity reactions and other adverse reactions.

PATIENT COUNSELING

Instruct to take ud; advise not to increase dose or dosing frequency. Inform that disintegrating tabs contain phenylalanine.

STORAGE

(Tab/Sol) 25°C (77°F); excursions permitted to 15-30°C (59-86°F). (Tab) Avoid exposure >30°C (86°F). (Sol) Protect from light. (Tab, Disintegrating) 20-25°C (68-77°F); excursions permitted to 15-30°C (59-86°F).

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