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Cefaclor (cefaclor)


Ceclor (Discontinued)


Cephalosporin (2nd generation)




Treatment of otitis media, pharyngitis, tonsillitis, and lower respiratory tract/urinary tract/skin and skin structure infections caused by susceptible strains of microorganisms.


General Dosing

Otitis media, pharyngitis, tonsillitis, and lower respiratory tract/urinary tract/skin and skin structure infections caused by susceptible strains of microorganisms

Usual: 250mg q8h

More Severe Infections (eg, Pneumonia)/Infections Caused by Less Susceptible Organisms: May double the dose

β-Hemolytic Streptococcal Infections: Administer for at least 10 days


General Dosing

≥1 Month of Age:
Usual: 20mg/kg/day q8h in divided doses

More Serious Infections/Infections Caused by Less Susceptible Organisms:
Usual: 40mg/kg/day q8h in divided doses
Max: 1g/day

β-Hemolytic Streptococcal Infections: Administer for at least 10 days

Total daily dosage may be divided and administered q12h for pharyngitis

Acute Otitis Media

≥1 Month of Age:
Usual: 40mg/kg/day q8h in divided doses
Max: 1g/day

Alternatively, total daily dosage may be divided and administered q12h


Oral route

Shake well before using
Add appropriate water volume in 2 portions to dry mixture in bottle; shake well after each addition
Refer to PI for appropriate water volume


Cap: 250mg, 500mg; Sus: 125mg/5mL [75mL, 150mL], 187mg/5mL [50mL, 100mL], 250mg/5mL [75mL, 150mL], 375mg/5mL [50mL, 100mL]


Caution in penicillin (PCN)-sensitive patients; cross-hypersensitivity among β-lactam antibiotics may occur. D/C if an allergic reaction occurs; serious acute hypersensitivity reactions may require treatment with epinephrine and other emergency measures as clinically indicated. Clostridium difficile-associated diarrhea (CDAD) (Sus)/Pseudomembranous colitis (Cap) reported. Consider CDAD/pseudomembranous colitis if diarrhea occurs. Institute appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of C. difficile, and surgical evaluation, as clinically indicated. Use in the absence of a proven or strongly suspected bacterial infection or prophylactic indication is unlikely to provide benefit and increases the risk of development of drug-resistant bacteria. May result in overgrowth of nonsusceptible organisms with prolonged use; take appropriate measures if superinfection develops. Lab test interactions may occur. Caution with markedly impaired renal function, history of GI disease particularly colitis, and in elderly. (Sus) If CDAD is suspected or confirmed, ongoing antibiotic use not directed against C. difficile may need to be discontinued.


GI symptoms, hypersensitivity reactions, eosinophilia, genital pruritus, moniliasis, vaginitis, serum-sickness-like reactions.


Renal excretion inhibited by probenecid. May increase anticoagulant effect of oral anticoagulants. (Cap) Concomitant use with warfarin may increase PT.


Category B, caution in nursing.


Cephalosporin (2nd generation); bactericidal, inhibits cell-wall synthesis.


Absorption: Fasting: Well-absorbed; Cmax=7mcg/mL (250mg), 13mcg/mL (500mg), 23mcg/mL (1g); Tmax=30-60 min. Distribution: Found in breast milk. Elimination: Urine (60-85% unchanged); T1/2=0.6-0.9 hrs (normal subjects), 2.3-2.8 hrs (anuria/complete absence of renal function).


Assess for hypersensitivity to cephalosporins/PCNs/other drugs, history of GI disease (particularly colitis), renal impairment, pregnancy/nursing status, and possible drug interactions. Perform appropriate culture and susceptibility tests to determine susceptible causative organisms.


Monitor for hypersensitivity reactions, CDAD/pseudomembranous colitis, development of superinfection or drug resistance, and other adverse reactions. Monitor renal function in the elderly and those with markedly impaired renal function. Monitor PT with warfarin.


Inform that drug only treats bacterial, not viral infections. Instruct to take exactly ud and that skipping doses or not completing full course of therapy may decrease effectiveness and increase the likelihood of bacterial resistance. (Sus) Instruct to contact physician as soon as possible if watery/bloody stools (with/without stomach cramps and fever) develop, even as late as 2 months after discontinuation.


20-25°C (68-77°F). Diluted Sol: Store in refrigerator after mixing. Discard unused portion after 14 days.


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