Buy Cardura Online

Cardura (doxazosin mesylate)

THERAPEUTIC CLASS

Alpha1 blocker (quinazoline)

DEA CLASS

RX

INDICATIONS

Treatment of HTN and of both the urinary outflow obstruction and obstructive and irritative symptoms associated with BPH.

ADULT DOSAGE

Hypertension

Initial: 1mg qd (am or pm)
Titrate: May increase to 2mg and thereafter if necessary to 4mg, 8mg, and 16mg qd depending on standing BP response

Benign Prostatic Hyperplasia

Initial: 1mg qd (am or pm)
Titrate: May increase to 2mg and thereafter to 4mg, and 8mg qd in 1- to 2-week intervals, depending on urodynamics and BPH symptomatology
Max: 8mg qd

DOSING CONSIDERATIONS

Elderly
Start at lower end of dosing range

ADMINISTRATION

Oral route

HOW SUPPLIED

Tab: 1mg*, 2mg*, 4mg*, 8mg* *scored

WARNINGS/PRECAUTIONS

May cause syncope and orthostatic hypotension (eg, dizziness, lightheadedness, vertigo), especially with 1st dose, dose increase, or if therapy is interrupted for more than a few days; restart using initial dosing regimen if therapy was discontinued for several days. Rule out carcinoma of the prostate prior to therapy. Priapism (rare) and leukopenia/neutropenia reported. Intraoperative floppy iris syndrome (IFIS) observed during cataract surgery. Caution with hepatic impairment and in the elderly.

ADVERSE REACTIONS

Dizziness, headache, fatigue/malaise, somnolence, edema, nausea, rhinitis.

DRUG INTERACTIONS

Caution with additional antihypertensive agents and drugs known to influence hepatic metabolism. Additive BP-lowering effects and symptomatic hypotension with PDE-5 inhibitors.

PREGNANCY AND LACTATION

Category C, caution in nursing.

MECHANISM OF ACTION

α1-blocker. BPH: Antagonizes phenylephrine (α1-agonist)-induced contractions and binds with high affinity to the α1c adrenoreceptor in prostate. HTN: Competitively antagonizes the pressor effects of phenylephrine and the systolic pressor effect of norepinephrine.

PHARMACOKINETICS

Absorption: Bioavailability (65%); Tmax=2-3 hrs. Distribution: Plasma protein binding (98%). Metabolism: Liver (extensive); O-demethylation or hydroxylation. Elimination: Feces (63%, 4.8% unchanged), urine (9%, trace amounts unchanged); T1/2=22 hrs.

ASSESSMENT

Assess for previous sensitivity to drug/quinazolines, hepatic impairment, prostate cancer, pregnancy/nursing status, and possible drug interactions.

MONITORING

Monitor for signs/symptoms of orthostatic hypotension, syncope, priapism, IFIS during cataract surgery, and other adverse reactions. Measure BP periodically, particularly 2-6 hrs after the 1st dose and with each increase in dose.

PATIENT COUNSELING

Inform of the possibility of syncopal and orthostatic symptoms, especially at the initiation of therapy; urge to avoid driving or hazardous tasks for 24 hrs after the 1st dose, dose increase, and interruption of therapy when treatment is resumed. Caution to avoid situations where injury could result should syncope occur. Advise to sit or lie down when symptoms of low BP occur. Instruct to report to physician if dizziness, lightheadedness, or palpitations are bothersome. Advise of possibility of priapism and to seek immediate medical attention if this occurs. Counsel to inform surgeon of drug use prior to cataract surgery.

STORAGE

25°C (77°F); excursions permitted to 15-30°C (59-86°F).

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