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Carafate (sucralfate)


Duodenal ulcer adherent complex




Short-term treatment (up to 8 weeks) of active duodenal ulcer (DU). (Tab) Maintenance therapy for DU patients at reduced dosage after healing of acute ulcers.


Active Duodenal Ulcer

1g qid on an empty stomach; continue for 4-8 weeks unless healing has been demonstrated by x-ray or endoscopic exam

Antacids may be prescribed prn for relief of pain but should not be taken w/in 1/2 hr before or after administration

Maint: 1g bid


Start at the lower end of dosing range


Oral route

Shake well before use


Sus: 1g/10mL [14 fl oz]; Tab: 1g* *scored


DU is a chronic, recurrent disease; a successful course of treatment should not be expected to alter post healing frequency or severity of duodenal ulceration. May impair excretion of absorbed aluminum with chronic renal failure or those receiving dialysis; aluminum accumulation and toxicity (aluminum osteodystrophy, osteomalacia, encephalopathy) reported with renal impairment. Caution with chronic renal failure and in elderly. (Sus) Episodes of hyperglycemia reported in diabetic patients; may need to adjust dose of antidiabetic treatment during therapy. (Tab) Aspiration with accompanying respiratory complications reported; caution with known conditions that may impair swallowing (eg, recent or prolonged intubation, tracheostomy, prior history of aspiration, dysphagia), or any other conditions that may alter gag and cough reflexes, or diminish oropharyngeal coordination or motility.


Constipation, diarrhea, N/V, pruritus, rash, dizziness, insomnia, back pain, headache, dry mouth, flatulence, gastric discomfort, indigestion, sleepiness, vertigo.


Simultaneous administration may reduce the extent of absorption of single doses of cimetidine, digoxin, fluoroquinolone antibiotics, ketoconazole, l-thyroxine, phenytoin, quinidine, ranitidine, tetracycline, and theophylline; administer separately when alterations in bioavailability are felt to be critical and monitor patients appropriately. Subtherapeutic PT with concomitant warfarin reported. Concomitant use with other products that contain aluminum (eg, aluminum-containing antacids) may increase the total body burden of aluminum.


Category B, caution in nursing.


DU-adherent complex; not established. Forms an ulcer-adherent complex that covers the ulcer site and protects it against further attack by acid, pepsin, and bile salts.


Absorption: GI (minimal). Elimination: Urine.


Assess for drug hypersensitivity or to any of the excipients, chronic renal failure or receiving dialysis, pregnancy/nursing status, and possible drug interactions. (Sus) Assess for diabetes mellitus. (Tab) Assess for known conditions that may impair swallowing or any other conditions that may alter gag and cough reflexes, or diminish oropharyngeal coordination or motility.


Monitor for aluminum accumulation and toxicity in patients with renal impairment and other adverse reactions. Monitor renal function. (Sus) Monitor for episodes of hyperglycemia. (Tab) Monitor for aspiration with accompanying respiratory complications.


Inform about the risks/benefits of treatment. Instruct to take exactly ud. Advise to contact physician if any side effects develop. Counsel about the possible drug interactions. Advise to notify physician if pregnant/nursing or planning to become pregnant.


(Sus) 20-25°C (68-77°F). Avoid freezing. (Tab) 15-30°C (59-86°F).


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