Buy Avodart Online

Avodart (dutasteride)


Type I and II 5 alpha-reductase inhibitor (5-ARI) (2nd generation)




Treatment of symptomatic BPH in men w/ an enlarged prostate, either as monotherapy or in combination w/ the α-adrenergic antagonist, tamsulosin.


Benign Prostatic Hyperplasia

1 cap (0.5mg) qd

W/ Tamsulosin:
1 cap (0.5mg) qd and tamsulosin 0.4mg qd


Oral route

Swallow whole; do not chew or open
Take w/ or w/o food


Cap: 0.5mg


Pregnancy, women of childbearing potential, pediatric patients.


Not approved for the prevention of prostate cancer. May decrease serum prostate specific antigen (PSA) concentration during therapy or in the presence of prostate cancer; establish a new baseline PSA at least 3 months after starting treatment and monitor PSA periodically thereafter. Any confirmed increase from the lowest PSA value while on treatment may signal presence of prostate cancer. May increase risk of high-grade prostate cancer. Prior to initiating treatment, consider other urological conditions that may cause similar symptoms; BPH and prostate cancer may coexist. Risk to male fetus; caps should not be handled by pregnant women or women who could become pregnant. Avoid donating blood until at least 6 months after last dose. Reduced total sperm count, semen volume, and sperm motility reported.


Impotence, decreased libido, breast disorders, ejaculation disorders.


Caution w/ potent, chronic CYP3A4 inhibitors (eg, ritonavir).


Category X, not for use in nursing.


Selective type I and II 5α-reductase inhibitor (2nd generation); inhibits conversion of testosterone to dihydrotestosterone, the androgen primarily responsible for initial development and subsequent enlargement of the prostate gland.


Absorption: Absolute bioavailability (60%); Tmax=2-3 hrs. Distribution: Vd=300-500L; plasma protein binding (99% albumin, 96.6% α-1 acid glycoprotein). Metabolism: Liver (extensive) via CYP3A4, 3A5; 4'-hydroxydutasteride, 1,2-dihydrodutasteride, 6-hydroxydutasteride (major metabolites). Elimination: Feces (5% unchanged, 40% metabolites), urine (<1% unchanged); T1/2=5 weeks.


Assess for urological conditions that may cause similar symptoms, previous hypersensitivity to the drug, and for possible drug interactions.


Monitor for signs/symptoms of prostate cancer and other urological diseases. Obtain new PSA baseline at least 3 months after starting treatment and monitor PSA periodically thereafter.


Inform of the importance of periodic PSA monitoring. Advise that therapy may increase risk of high-grade prostate cancer. Counsel that drug should not be handled by women who are pregnant or who could become pregnant, due to potential fetal risks; advise to wash area immediately w/ soap and water if contact is made. Instruct not to donate blood until at least 6 months after last dose.


25°C (77°F); excursions permitted to 15-30°C (59-86°F).


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