Buy Astelin Online

Astelin (azelastine hydrochloride)

THERAPEUTIC CLASS

H1 antagonist

DEA CLASS

RX

INDICATIONS

Treatment of the symptoms of seasonal allergic rhinitis in patients ≥5 yrs of age. Treatment of the symptoms of vasomotor rhinitis in patients ≥12 yrs of age.

ADULT DOSAGE

Vasomotor Rhinitis

Usual: 2 sprays/nostril bid

Seasonal Allergic Rhinitis

Usual: 1-2 sprays/nostril bid

PEDIATRIC DOSAGE

Vasomotor Rhinitis

≥12 Years:
Usual: 2 sprays/nostril bid

Seasonal Allergic Rhinitis

5-11 Years:
Usual: 1 spray/nostril bid

≥12 Years:
Usual: 1-2 sprays/nostril bid

DOSING CONSIDERATIONS

Elderly
Start at lower end of dosing range

ADMINISTRATION

Intranasal route

Priming
Prime before initial use by releasing 4 sprays or until a fine mist appears
When not used for ≥3 days, reprime w/ 2 sprays or until a fine mist appears

HOW SUPPLIED

Spray: 137mcg/spray [30mL]

WARNINGS/PRECAUTIONS

Occurrence of somnolence reported. May impair physical/mental abilities. Caution in elderly.

ADVERSE REACTIONS

Bitter taste, headache, somnolence, dysesthesia, rhinitis, cough, conjunctivitis, asthma, epistaxis, sinusitis, nasal burning, pharyngitis, paroxysmal sneezing.

DRUG INTERACTIONS

Avoid alcohol or other CNS depressants; additional reductions in alertness and CNS performance impairment may occur.

PREGNANCY AND LACTATION

Category C, caution in nursing.

MECHANISM OF ACTION

Antihistamine; exhibits histamine H1-receptor antagonist activity in isolated tissues.

PHARMACOKINETICS

Absorption: Tmax=2-3 hrs; bioavailability (40%). Distribution: Vd=14.5L/kg (PO/IV); plasma protein binding (88%, 97% metabolite). Metabolism: Oxidation via CYP450; desmethylazelastine (major active metabolite). Elimination: (PO) Feces (75%, <10% unchanged); T1/2=22 hrs (PO/IV).

ASSESSMENT

Assess for pregnancy/nursing status and possible drug interactions.

MONITORING

Monitor for somnolence and other adverse reactions.

PATIENT COUNSELING

Instruct to use only as prescribed. Caution patients against engaging in hazardous occupations requiring complete mental alertness and motor coordination (eg, driving a car or operating machinery). Instruct to avoid concurrent use with alcohol or other CNS depressants because additional reductions in alertness or CNS performance impairment may occur. Inform that therapy may lead to adverse reactions (eg, bitter taste, headache, somnolence). Instruct to consult physician if pregnant/nursing or planning to become pregnant. Instruct to keep out of reach of children and to seek medical help or call a poison control center immediately if a child accidentally ingests the medication.

STORAGE

20-25°C (68-77°F). Store upright. Protect from freezing.

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