Buy Arimidex Online

Arimidex (anastrozole)

THERAPEUTIC CLASS

Nonsteroidal aromatase inhibitor

DEA CLASS

RX

INDICATIONS

Adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer. First-line treatment of postmenopausal women with hormone receptor-positive or hormone receptor unknown locally advanced or metastatic breast cancer. Treatment of advanced breast cancer in postmenopausal women with disease progression following tamoxifen therapy.

ADULT DOSAGE

Breast Cancer

In postmenopausal women for adjuvant treatment of hormone receptor-positive early breast cancer; 1st-line treatment of hormone receptor-positive or hormone receptor unknown locally advanced or metastatic breast cancer; and treatment of advanced breast cancer w/ disease progression following tamoxifen therapy

Advanced Breast Cancer:
1mg qd; continue until tumor progression

Adjuvant Treatment of Early Breast Cancer:
1mg qd; administered for 5 years in a clinical trial

ADMINISTRATION

Oral route

Take w/ or w/o food

HOW SUPPLIED

Tab: 1mg

CONTRAINDICATIONS

Women who are or may become pregnant, premenopausal women.

WARNINGS/PRECAUTIONS

Increased incidence of ischemic cardiovascular (CV) events in women with preexisting ischemic heart disease reported. Decreases in bone mineral density (BMD) may occur. Elevated serum cholesterol reported.

ADVERSE REACTIONS

Hot flashes, asthenia, arthritis, pain, pharyngitis, HTN, depression, N/V, rash, osteoporosis, fractures, headache, bone pain, peripheral edema.

DRUG INTERACTIONS

Tamoxifen may decrease levels; avoid concomitant use. Avoid with estrogen-containing therapies.

PREGNANCY AND LACTATION

Category X, not for use in nursing.

MECHANISM OF ACTION

Nonsteroidal aromatase inhibitor; lowers serum estradiol concentrations and has no detectable effect on formation of adrenal corticosteroids or aldosterone.

PHARMACOKINETICS

Absorption: (Fasted state) Rapid. Tmax=2 hrs. Distribution: Plasma protein binding (40%). Metabolism: Liver via N-dealkylation, hydroxylation, and glucuronidation; triazole (major metabolite). Elimination: Urine and feces (85%); T1/2=50 hrs.

ASSESSMENT

Assess for hypersensitivity to drug, preexisting ischemic cardiac disease, premenopausal status, pregnancy/nursing status, and possible drug interactions.

MONITORING

Monitor for hypersensitivity reactions and other adverse reactions. Monitor BMD and serum cholesterol levels.

PATIENT COUNSELING

Inform that drug may cause fetal harm and is not for use in premenopausal women; instruct to d/c therapy if patient becomes pregnant and to immediately contact physician. Instruct to seek medical attention immediately if serious allergic reactions occur. Inform patients with preexisting ischemic heart disease that an increased incidence of CV events has been observed; advise to seek medical attention immediately if new or worsening chest pain or SOB occurs. Inform that drug may lower estrogen level, which may lead to a loss of the mineral content of bones, possibly decreasing the bone strength, leading to an increased risk of fractures. Inform that an increased level of cholesterol might be seen while receiving therapy. Instruct to notify physician if tickling, tingling, or numbness is experienced. Advise not to take drug with tamoxifen.

STORAGE

20-25°C (68-77°F).

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